Research projects

Extensive independent, scientific and clinical studies on anthocyanins.

Several independent research groups have conducted studies on the anthocyanins from MedPalett. A variety of issues have been thoroughly investigated, and to date, the results of these studies have been published in several different scientific journals. Additionally, extensive international research on anthocyanins has provided scientific support for their health-promoting properties.

References

Remission of impaired glucose tolerance by anthocyanin supplementation: a randomized, double-blind, and placebo-controlled trial
Lijun Yu · Senbate Amaliyati · Han Sun · Jie Dai · Yu Jiang · Zhe Li · Zhenhua Dong · Lina Zhao
Link: https://medpalett.no/wp-content/uploads/2026/03/Insulin-Medox.pdf

Anthocyanin-Rich Extracts from Bilberries and Blackcurrants in Human Health: A Narrative Review of Their Anti-Inflammatory and Antioxidant Effects
Carlos Escobar-Cervantes · Clotilde Vázquez-Martinez · Silvia Gómez-Senent · Alexandra Eva Henriquez-Linares · María Fasero-Laiz
Link: https://medpalett.no/wp-content/uploads/2026/03/JCM-2026.-Anthocyanin-Rich-Extracts-from-Bilberries-and-Blackcurrants-in-Human-Health.-A-Narrative-Review-of-Their-Anti-Inflammatory-and-Antioxidant-Effects.pdf

Anthocyanin supplementation in adults at risk for dementia: a randomized controlled trial on its cardiometabolic and anti‑inflammatory biomarker effects.
Miguel German Borda · Robinson Ramírez‑Vélez · Felipe Botero‑Rodriguez · Jonathan Patricio‑Baldera · Chiara de Lucia · Ilaria Pola · George E. Barreto · Khadija Khalifa · Anne Katrine Bergland · Miia Kivipelto · Tommy Cederholm · Henrik Zetterberg · Nicholas J. Ashton · Clive Ballard · Richard Siow · Dag Aarsland · on behalf of NJ FINGER.
Link: https://medpalett.no/wp-content/uploads/2025/10/s11357-025-01669-8.pdf

A randomized, placebo-controlled trial of purified anthocyanins on cognitive function in individuals at elevated risk for dementia: Analysis of inflammatory biomarkers toward personalized interventions. Exp Gerontol. 2024 Oct 15;196:112569.
Borda MG, Barreto GE, Baldera JP, de Lucia C, Khalifa K, Bergland AK, Pola I, Botero-Rodríguez F, Siow RC, Kivipelto M, Zetterberg H, Ashton NJ, Ballard C, Aarsland D; NJ FINGER.
Pubmed link: https://pubmed.ncbi.nlm.nih.gov/39226946/

Randomised Placebo-Controlled Study of Purified Anthocyanins on Cognition in Individuals at Increased Risk for Dementia. Am J Geriatr Psychiatry. 2023 Feb;31(2):141-151.
Aarsland D, Khalifa K, Bergland AK, Soennesyn H, Oppedal K, Holteng LBA, Oesterhus R, Nakling A, Jarholm JA, de Lucia C, Fladby T, Brooker H, Dalen I, Ballard C. A
Pubmed link: https://pubmed.ncbi.nlm.nih.gov/36372613/

Effects of Purified Anthocyanins in People at Risk for Dementia: Study Protocol for a Phase II Randomized Controlled Trial. Front Neurol. 2020 Sep 2;11:916.
Khalifa K, Bergland AK, Soennesyn H, Oppedal K, Oesterhus R, Dalen I, Larsen AI, Fladby T, Brooker H, Wesnes KA, Ballard C, Aarsland D.
Pubmed link: https://pubmed.ncbi.nlm.nih.gov/32982933/

Anthocyanins reduce inflammation and improve glucose and lipid metabolism associated with inhibiting nuclear factor-kappaβ activation and increasing PPAR-γ gene expression in metabolic syndrome subjects. Free Radical Biology and Medicine, pp. 15; 30-39.
Aboonabi A, A. A. (2020, February 13).

Cytoprotective effects of berry anthocyanins against induced oxidative stress and inflammation in primary human diabetic aortic endothelial cells. Chemico-Biological Interactions, p. 317: 108940.
Aboonabi A, S. I. (2020, January 11).

Purified Anthocyanin Supplementation Reduces Dyslipidemia, Enhances Antioxidant Capacity, and Prevents Insulin Resistance in Diabetic Patients. The Journal of Nutrition, pp. 145:4: 742-748.
Li D, Z. Y. (2015).

A dose-response evaluation of purified anthocyanins on inflammatory and oxidative biomarkers and metabolic risk factors in healthy young adults: A randomized controlled trial. Nutrition, p. 74 (2020) 110745.
Guo Y, Z. P. (2020).

Anthocyanin Supplementation Alleviates Antithrombotic Risk by Inhibiting Platelet Activity in Humans. Alternative therapies in health and medicine, pp. E-pub ahead of print.
Gaiz A, K. A. (2021, March 31).

Effects of anthocyanins on cardiovascular risk factors and inflammation in pre-hypertensive men: a double-blind randomized placebo-controlled crossover study. Journal of human hypertension, pp. 27: 100-106.
Hassellund SS, F. A. (2013).

The effect of anthocyanin supplementation in modulating platelet function in sedentary population: a randomized, double-blind, placebo-controlled cross-over trial. Brittish Journal of Nutrition, pp. 118: 368-374.
Thompson K, H. H. (2017).

Anthocyanin supplementation in alleviating thrombogenisis in overweight and obese population: a randomized, double-blind, placebo-controlled study. Jornal of functional foods, pp. 32: 313-138.
Thompson K, P. W. (2017).

Role of purified anthocyanins in improving cardiometabolic risk factors in chinese men and women with prediabetes or early utreated diabetes – A randomized controlled trial. Nutrients, p. 9: 1104.
Yang L, L. W. (2017).

Anthocyanins in berries exhibited anti-atherogenicity and antiplatelet activities in a metabolic syndrome population. Nutrition Research, pp. 76: 82-93.
Aboonabi A, R. M. (2020, February 24).

Anthocyanin supplementation improves serum LDL- and HDL-cholesterol concentrations associated with the inhibition of cholesteryl ester transfer protein in dyslipidemic subjects. American Journal of Clinical Nutrition, pp. 90:3:485-492.
Qin Y, X. M. (2009).

Dose-dependent effects of anthocyanin supplementation on platelet function in subjects with dyslipidemia: A randomized clinical trial. EBio Medicine, p. 70 (20219 103533.
Tian Z, L. K. (2021, August 21).

Anthocyanin supplementatio at different doses improves cholesterol efflux capacity in subjects with dyslipidemia – a randomized controlled trial. European Journal of Clinical Nutrition.
Xu Z, X. J. (2020, April 21).

Anthocyanin supplementation improves anti-oxidative and anti-inflammatory capacity in a dose-dependent manner in subjects with dyslipidemia. Redox Biology, p. 32: 101474.
Zhang H, Z. X. (2020, February 20).

Dose-dependent reductions in plasma ceramides after anthocyanin supplementation are associated with improvements in plasma lipids and cholesterol efflux capacity in dyslipidemia: A randomized controlled trial. Clinical Nutrition, p. Article in press.
Zhao Y, X. H. (2020, October 15).

Anthocyanin supplementation improves HDL-associated paraoxonase 1 activity and enhances cholesterol efflux capacity in subjects with hypercholesterolemia. The journal of clinical endocrinology and metabolism, pp. 99::561-569.
Zhu Y, H. X. (2014).

Anti-inflammatory effect of purified dietary anthocyanin in adults with hypercholesterolemia: a randomized controlled trial. Nutrition, metabolisma and cardiovascular diseases, pp. 9:843-849.
Zhu Y, L. W. (2013).

Purified anthocyanin supplementation improves endothelial function via NO-cGMP activation in hypercholesterolemic individuals. Clinical Chemistry, pp. 57:11: 1524-1533.
Zhu Y, X. M. (2011).

Berry anthocyanins reduce proliferation of human colorectal carcinoma cells by inducing caspace-3 activation and p21 upregulation. Mol Med Reports, pp. 14:1397-1403.
Anwar S, F. D. (2016).

Anthocyanins inhibit airway inflammation and hyperresponsiveness in a murine asthma model. Food and Chemical Toxicology, pp. 45:1459-1467.
Park S-J, S. W.-H.-W.-J. (2007, February 10).

Anthocyanin supplementation inhibits secretion of pro-inflammatory cytokines in overweight and obese individyals. Journal of Functional Foods, p. 64: 103596.
Vugic L, C. N. (2019, October 31).