Forskningsprosjekter
MedPaletts antocyaner og produkt Medox har fascinert forskere over hele verden i over 20 år fra Australia og Kina til Italia og Canada, men til og med i Sverige og Norge. Hittil er det publisert over 40 uavhengige, vitenskapelige, kliniske studier med antocyaner/Medox levert fra MedPalett og flere er i gang.
Linker til forskningsprosjektene:
- Tian Z, Li K, Fan D, Zhao Y, Gao X, Ma X, Xu L, Shi Y, Ya F, Zou J, Wang P, Mao Y, Ling W, Yang Y. Dose-dependent effects of anthocyanin supplementation on platelet function in subjects with dyslipidemia: A randomised clinical trial. EBioMedicine 2021;70:103533
- Nikbakht E, Singh I, Vider J, Williams LT, Vugic L, Gaiz A, Kundur AR, Colson N. Potential of anthocyanin as an anti-inflammatory agent: a human clinical trial on type 2 diabetic, diabetic at-risk and healthy adults. Inflamm Res 2021;70:275-84.
- Martin-Gonzalez MZ, Palacios-Jordan H, Mas-Capdevila A, Rodriguez MA, Bravo FI, Muguerza B, Aragones G. A multifunctional ingredient for the management of metabolic syndrome in cafeteria diet-fed rats. Food Funct 2021,12:815
- Grohmann T, Litts C, Horgan G, Zhang X, Hoggard N, Russell W, de Roos B. Efficacy of Bilberry and Grape Seed Extract Supplement Interventions to Improve Glucose and Cholesterol Metabolism and Blood Pressure in Different Populations—A Systematic Review of the Literature. Nutrients 2021, 13, 1692.
- Gaiz A, Kundur AR, Nikbakht E, Vugic L, Colson N, Shibeeb S, Singh I. Anthocyanin Supplementation Alleviates Antithrombotic Risk by Inhibiting Platelet Activity in Humans. Altern Ther Health Med. 2021 Mar 31;AT6369
- Carrizzo A, Lizio R, Di Pietro P, Ciccarelli M, Damato A, Venturini E, Iannece P, Sommella E, Campiglia P, Ockermann P, Vecchione C. Healthberry 865 ® and Its Related, Specific, Single Anthocyanins Exert a Direct Vascular Action, Modulating Both Endothelial Function and Oxidative Stress. Antioxidants (Basel) 2021 Jul 26;10(8):1191. doi: 10.3390/antiox10081191
- Arruda HS, Silva EK, Peixoto Araujo NM, Pereira GA, Pastore GM, Marostica Junior MR. Anthocyanins Recovered from Agri-Food By-Products Using Innovative Processes: Trends, Challenges, and Perspectives for Their Application in Food Systems. Molecules 2021, 26, 2632.
- Zhao Y, Xu H, Tian Z, Wang X, Xu L, Li K, Gao X, Fan D, Ma X, Ling W, Yang Y. Dose-dependent reductions in plasma ceramides after anthocyanin supplementation are associated with improvements in plasma lipids and cholesterol efflux capacity in dyslipidemia: A randomized controlled trial. Clin Nutr 2020 doi.org/10.1016/j.clnu.2020.10.014
- Zhang H, Xu Z, Zhao H, Wang X, Pang J, Li Q, Yang Y, Ling W. Anthocyanin supplementation improves anti-oxidative and anti-inflammatory capacity in a dose-response manner in subjects with dyslipidaemia. Redox Biol 2020;32:101474
- Yang L, Liu Z, Ling W, Wang L, Wang C, Ma J, Peng X, Chen J. Effect of Anthocyanins Supplementation on Serum IGFBP-4 Fragments and Glycemic Control in Patients with Fasting Hyperglycemia: A Randomized Controlled Trial. Diabetes Metab Syndr Obes 2020;13:3395– 3404
- Yang L, Ling W, Qiu Y, Liu Y, Wang L, Yang J, Wang C, Ma J. Anthocyanins increase serum adiponectin in newly diagnosed diabetes but not in prediabetes: a randomized controlled trial Nutr Metab (Lond) 2020;17:78 doi.org/10.1186/s12986-020-00498-0
- Yang L, Qiu Y, Ling W, Liu Z, Yang L, Wang C, Peng X, Wang L, Chen J. Anthocyanins regulate serum adipsin and visfatin in patients with prediabetes or newly diagnosed diabetes: a randomized controlled trial. Eur J Nutr 2020 doi.org/10.1007/s00394-020-02379-x
- Xu Z, Xie J, Zhang H, Pang J, Li Q, Wang X, Xu H, Sun X, Zhao H, Yang Y, Ling W. Anthocyanin supplementation at different doses improves cholesterol efflux capacity in subjects with dyslipidaemia – a randomized controlled trial. Eur J Clin Nutr 2020 doi.org/10.1038/s41430- 020-0609-4
- Vugic L, Colson N, Nikbakht E, Gaiz A, Holland OJ, Kundur AR, Singh I. Anthocynins supplementation inhibits secretion of pro-inflammatory cytokines in overweight and obese individuals. J Funct Foods 2020;64:103596
- Guo Y, Zhang P, Liu Y, Zha L, Ling W, Guo H. A dose-response evaluation of purified anthocyanins on inflammatory and oxidative biomarkers and metabolic risk factors in healthy young adults: A randomized controlled trial. Nutrition 2020;74:110745
- Chan SW & Tomlinson B. Effects of bilberry supplementation on metabolic and cardiovascular disease risk. Molecules 2020;25:1653
- Aboonabi A & Aboonabi A. Anthocyanins reduce inflammation and improve glucose and lipid metabolism associated with inhibiting nuclear factor-kappaB activation and increasing PPAR- γ gene expression in metabolic syndrome subjects. Free Radic Biol Med 2020;150:30-9
- Aboonabi A, Meyer RR, Gaiz A, Singh I. Anthocyanins in berries exhibited anti-atherogenicity and anti-platelet activities in a metabolic syndrome population. Nut Res 2020;76:82-93
- Aboonabi A, Singh I, Meyer RR. Cytoprotective effects of berry anthocyanins against induced oxidative stress and inflammation in primary human diabetic aortic endothelial cells. Chem Biol Interact 2020;317:108940
- Rodriguez-Mateos A, Istas G, Boschek L, Feliciano RP, Mills CE, Boby C, Gomez-Alonso S, Milenkovic D, Heiss C. Circulating Anthocyanin Metabolites Mediate Vascular Benefits of Blueberries: Insights From Randomized Controlled Trials, Metabolomics, and Nutrigenomics J Gerontol A Biol Sci Med Sci 2019;74(7):967–76
- Qian X, Wang X, Luo J, Liu Y, Pang J, Zhang H, Xu Z, Xie J, Jiang X, Ling W. Hypouricemic and nephroprotective roles of anthocyanins in hyperuricemic mice. Food Funct., 2019, DOI:10.1039/C8FO02124D
- Muscarà C, Molonia MS, Speciale A, Bashllari R, Cimino F, Occhiuto C, Saija A, Cristani M. Anthocyanins ameliorate palmitate-induced inflammation and insulin resistance in 3T3-L1 adipocytes. Phytother Res 2019;33:1888–97
- Bergland AK, Soennesyn H, Dalen I, Rodriguez-Mateos A, Berge RK, Giil LM, Rajendran L, Siow R, Tassotti M, Larsen AI, Aarsland D. Effects of Anthocyanin Supplementation on Serum Lipids, Glucose, Markers of Inflammation and Cognition in Adults With Increased Risk of Dementia – A Pilot Study. Front. Genet. 2019;10:536.
- Yang L, Ling W, Yang Y, Chen Y, Tian Z, Du Z, Chen J, Xie Y, Liu Z, Yang L. Role of Purified Anthocyanins in Improving Cardiometabolic Risk Factors in Chinese Men and Women with Prediabetes or Early Untreated Diabetes—A Randomized Controlled Trial Nutrients 2017;9(10):1104
- Thompson K, Pederick W, Singh I, Santhakumar AB. Anthocyanin supplementation in alleviating thrombogenesis in overweight and obese population: A randomized, double-blind, placebo-controlled study. J Funct Food 2017;32:131–138
- Thompson K, Hosking H, Pederick W, Singh I, Santhakumar AB. The effect of anthocyanin supplementation in modulating platelet function in sedentary population: a randomised, double-blind, placebo-controlled, cross-over trial. Br J Nutr 2017;118:368–374
- Zhang X, Zhu Y, Song F, Yao Y, Ya F, Li D, Ling W, Yang Y. Effects of purified anthocyanin supplementation on platelet chemokines in hypercholesterolemic individuals: a randomized controlled trial. Nutr Metab 2016;13:86
- Parrado-Fernandez C, Sandebring-Matton A, Rodriguez-Rodriguez P, Aarsland D, Cedazo- Minguez A. Anthocyanins protect from complex I inhibition and APPswe mutation through modulation of the mitochondrial fission/fusion pathways. Biochim Biophys Acta 2016;1862:2110-8
- Cristani M, Speciale A, Mancari F, Arcoraci T, Ferrari D, Fratantonio D, Saija A, Cimino F, Trombetta D. Protective activity of an anthocyanin-rich extract from bilberries and blackcurrants on acute acetaminophen-induced hepatotoxicity in rats. Nat Prod Res 2016 DOI: 10.1080/14786419.2016.1160235
- Anwar S, Fratantonio D, Ferrari D, Saija A, Cimino F, Speciale A. Berry anthocyanins reduce proliferation of human colorectal carcinoma cells by inducing caspase-3 activation and p21 upregulation. Mol Med Rep 2016;14:1397-1403
- Zhang P, Chen F, Li D, Ling W, Guo H. A CONSORT-Compliant, Randomized, Double-Blind, Placebo-Controlled Pilot Trial of Purified Anthocyanin in Patients With Nonalcoholic Fatty Liver Disease. Medicine 2015;94(20):e758
- Tang X, Shen T, Jiang X, Xia M, Sun X, Guo H, Ling W. Purified Anthocyanins from Bilberry and Black Currant Attenuate Hepatic Mitochondrial Dysfunction and Steatohepatitis in Mice with Methionine and Choline Deficiency. J. Agric. Food Chem. 2015;63:552−561
- Li D, Zhang Y, Liu Y, Sun R, Xia M. Purified Anthocyanin Supplementation Reduces Dyslipidemia, Enhances Antioxidant Capacity and Prevents Insulin Resistance in Diabetic Patients. J Nutr 2015;145(4):742-8
- Hoek-van den Hil EF, van Schothorst EM, van der Stelt I, Swarts HJM, van Vliet M, Amolo T, Vervoort JJM, Venema D, Hollman PCH, Rietjens IMCM, Keijer J. Direct comparison of metabolic health effects of the flavonoid quercetin, hesperetin, epicatechin, apigenin and anthocyanins in high-fat-diet-fed mice. Genes Nutr (2015) 10:23 DOI 10.1007/s12263-015-0469-z
- Zhu Y, Huang X, Zhang Y, Wang Y, Liu Y, Sun R, Xia M. Anthocyanin Supplementation Improves HDL Associated Paraoxonase 1 Activity and Enhances Cholesterol Efflux Capacity in Subjects With Hypercholesterolemia. J Clin Endocrinol Metab February 2014;99(2):561–9
- Song F, Zhu Y, Shi Z, Tian J, Deng X, Ren J, Andrews MC, Ni H, Ling W, Yang Y. Plant food anthocyanins inhibit platelet granule secretion in hypercholesterolaemia: Involving the signalling pathway of PI3K–Akt. Thromb Haemost 2014; 112: 981–991
- Zhu Y, Ling W, Guo H, Song F, Ye Q, Zou T, Li D, Zhang Y, Li G, Xiao Y, Liua F, Li Z, Shi Z, Yang Y. Anti-inflammatory effect of purified dietary anthocyanin in adults with hypercholesterolemia: A randomized controlled trial. Nutr Metab Cardiovas 2013;23(9):843- 9
- Cimino F, Speciale A, Anwar S, Canali R, Ricciardi E, Virgili F, Trombetta D, Saija A. Anthocyanins protect human endothelial cells from mild hyperoxia damage through modulation of Nrf2 pathway Genes Nutr 2013;8:391–399
- Hassellund SS, Flaa A, Kjeldsen SE, Seljeflot I, Karlsen A, Erlund I, Rostrup M. Effects of anthocyanins on cardiovascular risk factors and inflammation in pre-hypertensive men: a double-blind randomized placebo-controlled crossover study. J Hum Hypertens 2013;27:100- 6
- Hassellund SS, Flaa A, Sandvik L, Kjeldsen SE, Rostrup M. Effects of anthocyanins on blood pressure and stress reactivity: a double-blind randomized placebo-controlled crossover study J Hum Hypertens 2012;26:396–404
- Wang D, Xia M, Yan X, Li D, Wang L, Xu Y, Jin T, Ling W. Gut Microbiota Metabolism of Anthocyanin Promotes Reverse Cholesterol Transport in Mice via Repressing miRNA-10b. Circ Res 2012;111:967–981
- Zhu Y, Xia M, Yang Y, Liu F, Li Z, Hao Y, Mi M, Jin T, Ling W. Purified Anthocyanin Supplementation Improves Endothelial Function via NO-cGMP Activation in Hypercholesterolemic Individuals. Clin Chem 2011;57(11):1524–33
- Qin Y, Xia M, Ma J, Hao YT, Liu J, Mou HY, Cao L, Ling WH. Anthocyanin supplementation improves serum LDL- and HDL-cholesterol concentrations associated with the inhibition of cholesteryl ester transfer protein in dyslipidemic subjects. Am J Clin Nutr 2009;90:485–92
- Park SJ, Shin WH, Seo JW, Kim EJ. Anthocyanins inhibit airway inflammation and hyperresponsiveness in a murine asthma model. Food Chem Toxicol 2007;45:1459–1467
- Karlsen A, Retterstøl L, Laake P, Paur I, Kjølsrud-Bøhn S, Sandvik L, Blomhoff R. Anthocyanins Inhibit Nuclear Factor-kB Activation in Monocytes and Reduce Plasma Concentrations of Pro-Inflammatory Mediators in Healthy Adults. J. Nutr. 2007;137:1951-54